Reducing vascular access morbidity: a comparative trial of two vascular access monitoring strategies

Nephrol Dial Transplant. 2003 Jun;18(6):1174-80. doi: 10.1093/ndt/gfg122.


Background: Thrombosis is the primary cause of access failure in polytetrafluoroethylene grafts and arteriovenous fistulas. It can lead to significant patient and access morbidity and mortality, and is difficult to prevent medically. Intervention is largely limited to maximizing access patency by detecting culprit lesions early and intervening with angioplasty or surgical revision. The most efficacious monitoring strategy is undetermined.

Methods: This 3 year prospective study took advantage of a change in monitoring strategy used in a large dialysis centre to compare the efficacy of two methods used to monitor grafts and fistulas in order to prevent access thrombosis. Accesses were monitored using Duplex ultrasonography in year 1, while the saline ultrasound dilution technique (Transonic) became the primary monitoring strategy in year 3 (year 2 was a transition year). Risk factors for thrombosis were determined using multivariate survival analysis, and the performance of Duplex ultrasonography and Transonic monitoring was assessed.

Results: A total of 303 656 access days at risk were assessed, with 344, 385 and 425 accesses in years 1, 2 and 3, respectively. The total thrombosis rate was 1.01/1000 access days in year 1 compared with 0.66/1000 access days in year 3. This was accomplished despite a reduction in procedure rates of 55% for angiograms, 13% for angioplasties and 31% for thrombolysis.

Conclusion: Low flow rates detected using Transonic monitoring were associated with increased thrombosis, while stenosis detected using Duplex ultrasonography was not a strong predictor of incipient thrombosis; however, these different access characteristics were compared using monitoring techniques that may be ideal in different clinical situations.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arteriovenous Shunt, Surgical / adverse effects*
  • Female
  • Graft Occlusion, Vascular / diagnostic imaging*
  • Humans
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Proportional Hazards Models
  • Prospective Studies
  • Renal Dialysis
  • Risk Factors
  • Sensitivity and Specificity
  • Survival Analysis
  • Thrombosis / diagnostic imaging
  • Thrombosis / etiology
  • Thrombosis / prevention & control*
  • Ultrasonography / methods