The complexities of skeletal biology

Nature. 2003 May 15;423(6937):316-8. doi: 10.1038/nature01654.


For a long time, the skeleton was seen as an amorphous tissue of little biological interest. But such a view ignored the large number of genetic and degenerative diseases affecting this organ. Over the past 15 years, molecular and genetic studies have modified our understanding of skeletal biology. By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities.

Publication types

  • Review

MeSH terms

  • Bone Development
  • Bone and Bones / cytology
  • Bone and Bones / embryology
  • Bone and Bones / pathology
  • Bone and Bones / physiology*
  • Cell Differentiation
  • Humans