[Photodynamic therapy: extended indication]

Ophthalmologe. 2003 May;100(5):384-90. doi: 10.1007/s00347-002-0723-9.
[Article in German]

Abstract

Objective: Evaluation of efficacy of photodynamic therapy (PDT) for classic choroidal neovascularization (CNV) beyond the common indication.

Methods: A group of 256 patients was treated with photodynamic therapy from January to December 2000. Ten of these patients had a predominantly classic CNV due to angioid streaks (5), parafoveal telangiectasia (2), or chorioretinitis (3). In two patients an idiopathic origin of the CNV was presumed. Another 21 patients showed a juxtafoveal classic membrane (12) or a recurrence after laser photocoagulation (9). Visual acuity was evaluated, also in correlation to age and CNV size. Continuous follow-up of CNV and leakage size was performed with fluorescein angiography.

Results: Overall 85% of the patients showed visual stabilization or improvement during an average observation period of 10.5 months. A correlation was found between age and visual improvement favoring younger patients; however, no correlation was found between visual improvement and CNV size. CNV and leakage size decreased moderately over the 9-month follow-up from 1.81/3.45 mm(2) to 1.61/2.60 mm(2).

Conclusion: PDT shows efficacy for classic choroidal neovascularization beyond the common indication.

MeSH terms

  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / etiology
  • Epiretinal Membrane / diagnosis
  • Epiretinal Membrane / drug therapy
  • Epiretinal Membrane / etiology
  • Fluorescein Angiography / drug effects
  • Follow-Up Studies
  • Hematoporphyrin Photoradiation*
  • Humans
  • Photosensitizing Agents / therapeutic use
  • Porphyrins / therapeutic use
  • Retrospective Studies
  • Treatment Outcome
  • Verteporfin
  • Visual Acuity / drug effects

Substances

  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin