Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 447 (5), 510-8

The Sodium/Glucose Cotransport Family SLC5

Affiliations
Review

The Sodium/Glucose Cotransport Family SLC5

Ernest M Wright et al. Pflugers Arch.

Erratum in

  • Pflugers Arch. 2004 Feb;447(5):813-5

Abstract

The sodium/glucose cotransporter family (SLCA5) has 220 or more members in animal and bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the central nervous system. The functions of nine have been revealed by studies using heterologous expression systems: six are tightly coupled plasma membrane Na(+)/substrate cotransporters for solutes such as glucose, myo-inositol and iodide; one is a Na(+)/Cl(-)/choline cotransporter; one is an anion transporter; and another is a glucose-activated ion channel. The exon organization of eight genes is similar in that each comprises 14-15 exons. The choline transporter (CHT) is encoded in eight exons and the Na(+)-dependent myo-inositol transporter (SMIT) in one exon. Mutations in three genes produce genetic diseases (glucose-galactose malabsorption, renal glycosuria and hypothyroidism). Members of this family are multifunctional membrane proteins in that they also behave as uniporters, urea and water channels, and urea and water cotransporters. Consequently it is a challenge to determine the role(s) of these genes in human physiology and pathology.

Similar articles

  • Glucose Transport Families SLC5 and SLC50
    EM Wright. Mol Aspects Med 34 (2-3), 183-96. PMID 23506865. - Review
    There are three families of glucose transporters in the human genome, SLC2, SLC5 and SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The huma …
  • Surprising Versatility of Na+-glucose Cotransporters: SLC5
    EM Wright et al. Physiology (Bethesda) 19, 370-6. PMID 15546855. - Review
    SLC5 is an ancient gene family with 11 members in the human genome. These membrane proteins have diverse, multiple functions ranging from actively transporting solutes, i …
  • Functional Studies of a Chimeric Protein Containing Portions of the Na(+)/glucose and Na(+)/myo-inositol Cotransporters
    MJ Coady et al. Biochim Biophys Acta 1466 (1-2), 139-50. PMID 10825438.
    We obtained cDNA chimeras between Na/glucose cotransporter (SGLT1) and the homologous Na(+)/myo-inositol cotransporter (SMIT) by creating random chimeras in plasmids. Of …
  • Structure and Function of the Na+/glucose Cotransporter
    EM Wright et al. Acta Physiol Scand Suppl 643, 257-64. PMID 9789568. - Review
    Cotransporters are a major class of membrane transport proteins that are responsible for the accumulation of nutrients, neurotransmitters, osmolytes and ions in cells fro …
  • Urea Transport by Cotransporters
    DW Leung et al. J Physiol 528 Pt 2 (Pt 2), 251-7. PMID 11034615.
    The rabbit Na+-glucose cotransporter (rbSGLT1) was expressed in Xenopus laevis oocytes and urea transport in rbSGLT1 and non-injected (control) oocytes was studied using …
See all similar articles

Cited by 126 PubMed Central articles

See all "Cited by" articles

References

    1. J Biol Chem. 2001 Jan 19;276(3):1728-34 - PubMed
    1. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7789-94 - PubMed
    1. J Physiol. 2002 Jul 1;542(Pt 1):53-60 - PubMed
    1. Kidney Int. 2001 Aug;60(2):408-11 - PubMed
    1. J Biol Chem. 1996 Apr 26;271(17 ):10029-34 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback