Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in rats

Neurosci Lett. 2003 May 29;343(1):25-8. doi: 10.1016/s0304-3940(03)00312-4.


Lipopolysaccharide (LPS) injected intraperitoneally (i.p.) is known to decrease food intake. Ghrelin is a peptide hormone produced by the stomach with a potent orexigenic effect and plasma levels that are inversely correlated with the fed state. We examined changes in plasma ghrelin levels 3 h after LPS (100 microg/kg, i.p.) in fasted rats with or without a 1 h re-feeding period. LPS injection decreased the fasting levels of ghrelin by 51+/-5% compared with preinjection values while i.p. vehicle did not modify ghrelin levels in fasted rats. LPS at this dose reduced fasting-induced food intake by 60% compared with the i.p. vehicle group. Re-feeding decreased plasma ghrelin levels by 58+/-3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Temperature / drug effects
  • Escherichia coli / metabolism
  • Fasting / physiology*
  • Feeding Behavior / drug effects
  • Feeding Behavior / physiology
  • Ghrelin
  • Injections
  • Lipopolysaccharides / administration & dosage*
  • Male
  • Peptide Hormones / blood*
  • Postprandial Period / drug effects*
  • Postprandial Period / physiology*
  • Rats
  • Rats, Sprague-Dawley


  • Ghrelin
  • Lipopolysaccharides
  • Peptide Hormones