Mycophenolate Mofetil as an Immunomodulatory Agent in the Treatment of Chronic Ocular Inflammatory Disorders

Ophthalmology. 2003 May;110(5):1061-5. doi: 10.1016/S0161-6420(03)00092-7.

Abstract

Purpose: To evaluate the outcomes of patients with chronic ocular inflammatory disease treated with mycophenolate mofetil as an immunosuppressive and steroid-sparing agent.

Design: Retrospective noncomparative interventional case series.

Participants: All patients with ocular inflammatory disease treated with mycophenolate mofetil at a single institution between 1998 and 2001.

Methods: Charts of patients seen on the Ocular Immunology and Uveitis Service at the Massachusetts Eye and Ear Infirmary were reviewed. Patients with chronic ocular inflammatory disease were included in the study.

Main outcome measures: Control of inflammation, steroid-sparing effect, visual acuity, and adverse reactions were measured.

Results: A total of 54 patients were evaluated. Control of ocular inflammation with mycophenolate mofetil as monotherapy was achieved in 35 patients (65%) and in 67 eyes (62%), and a steroid-sparing effect was achieved in 29 (54%) patients. Visual acuity was maintained or improved in 51 patients (94%) and in 97 eyes (90%). Side effects requiring discontinuation of medication occurred in 10 patients (18%). There was neither long-term morbidity nor mortality due to mycophenolate mofetil.

Conclusions: Mycophenolate mofetil is effective in the treatment of patients with steroid-dependent or -resistant chronic ocular inflammatory disorders that fail to respond to conventional steroid treatment. It is a safe and effective steroid-sparing immunomodulatory agent and can be considered an important addition to our armamentarium in the care of patients with ocular inflammatory disease.

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Endophthalmitis / drug therapy*
  • Female
  • Humans
  • IMP Dehydrogenase / antagonists & inhibitors
  • Immunosuppressive Agents / therapeutic use*
  • Inflammation / drug therapy
  • Male
  • Middle Aged
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use*
  • Retrospective Studies
  • Visual Acuity

Substances

  • Immunosuppressive Agents
  • IMP Dehydrogenase
  • Mycophenolic Acid