Abstract
The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Connexin 43 / metabolism
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Connexins / metabolism
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Drosophila / growth & development
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Drosophila / metabolism
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Drosophila Proteins / metabolism
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Eye / growth & development
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Gap Junctions / physiology*
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Humans
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Lens, Crystalline / metabolism
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Membrane Proteins / metabolism
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Nerve Tissue Proteins / metabolism
Substances
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Connexin 43
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Connexins
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Drosophila Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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ogre protein, Drosophila
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shakB protein, Drosophila