Growth in steroid-responsive nephrotic syndrome: a study of 85 pediatric patients

Pediatr Nephrol. 2003 Aug;18(8):789-95. doi: 10.1007/s00467-003-1142-0. Epub 2003 May 16.

Abstract

The statural growth of 85 patients with steroid-responsive idiopathic nephrotic syndrome, attending the Pediatric Nephrology Unit, Children's Institute, Hospital das Clínicas School of Medicine, University of São Paulo, with a minimum follow-up of 3 years, was evaluated. Analysis of the patient population as a group did not show any significant alterations in the height Z score and the mean height percentile between the first (-0.59 and 33.9, respectively) and last consultation (-0.57 and 34.8, respectively). Analysis of each individual patient allowed the definition of two subgroups. Subgroup A, which achieved growth improvement, was composed of 47 children-initial Z score and mean initial height percentile of -0.91 and 24.0, respectively; final Z score and mean height percentile of -0.30 and 40.7, respectively ( P=0.00). Subgroup B, which showed growth retardation, was composed of 38 children-initial Z score and mean initial height percentile of -0.19 and 46.2, respectively; final Z score and mean height percentile of -0,9 and 27.5, respectively ( P=0.00). The following factors were significantly different when both subgroups were compared: (1) total duration of prednisone therapy and total prednisone dose were greater in subgroup B; (2) the final chronological age of patients using prednisone was higher in subgroup B; (3) the pubertal growth spurt in subgroup B showed attenuation and retardation.

MeSH terms

  • Adolescent
  • Adult
  • Biopsy
  • Child
  • Child Development / drug effects*
  • Child, Preschool
  • Female
  • Glucocorticoids / adverse effects*
  • Growth Disorders / chemically induced*
  • Humans
  • Male
  • Nephrotic Syndrome / drug therapy*
  • Nephrotic Syndrome / pathology
  • Prednisone / adverse effects*
  • Puberty
  • Retrospective Studies

Substances

  • Glucocorticoids
  • Prednisone