Deficit in long-term contextual fear memory induced by blockade of beta-adrenoceptors in hippocampal CA1 region

Eur J Neurosci. 2003 May;17(9):1947-52. doi: 10.1046/j.1460-9568.2003.02620.x.


The present study investigated the effects of intra-CA1 infusion of d,l-propranolol, the beta-adrenergic antagonist, on memory for contextual fear conditioning. d,l-Propranolol administered 5 min ('0 h') postconditioning impaired long-term but not short-term contextual fear memory, while it was ineffective when administered 6 h postconditioning, suggesting that there is a time window for beta-adrenoceptors to play a role. Thus, we conclude that beta-adrenoceptors in area CA1 are involved in regulating consolidation of contextual fear memory, with '0 h' but not 6 h post-training, a sensitive time point for the beta-adrenergic involvement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / toxicity*
  • Animals
  • Conditioning, Psychological / drug effects
  • Conditioning, Psychological / physiology
  • Fear / drug effects*
  • Fear / physiology
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • Immobilization / physiology
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Memory Disorders / chemically induced*
  • Memory Disorders / physiopathology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Adrenergic, beta / physiology


  • Adrenergic beta-Antagonists
  • Receptors, Adrenergic, beta