An "experimental" epidemic of Reiter's syndrome revisited. Follow-up evidence on genetic and environmental factors

Ann Intern Med. 1976 May;84(5):564-6. doi: 10.7326/0003-4819-84-5-564.

Abstract

The relation between a specific infective event (shigellosis), a specific disease entity (Reiter's syndrome), and a specific histocompatibility antigen (HL-A B27) is documented by follow-up study of an epidemic of post-Shigella Reiter's syndrome. Five of the original 10 patients have been traced, HL-A typed, and clinically assessed 13 years after the initial episode. One of the 5 has minimal disease, remains symptom-free, and is HL-A B27-negative. The remaining 4 have followed a chronic course, have persistent active disease, and are HL-A B27-positive. It is estimated that after this single episode of shigellosis, from one sixth to one third of the persons who were HL-A B27-positive developed Reiter's syndrome. The prognosis for postdysenteric Reiter's syndrome must be guarded, especially in the subject who is B27-positive.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Reactive / etiology
  • Arthritis, Reactive / genetics
  • Arthritis, Reactive / immunology*
  • Disease Outbreaks*
  • Dysentery, Bacillary / complications*
  • Dysentery, Bacillary / immunology
  • Follow-Up Studies
  • HLA Antigens / analysis*
  • Histocompatibility Antigens / analysis*
  • Humans
  • Male

Substances

  • HLA Antigens
  • Histocompatibility Antigens