Uremic malnutrition: new insights into an old problem

Semin Dial. May-Jun 2003;16(3):224-32. doi: 10.1046/j.1525-139x.2003.16046.x.


Uremic malnutrition is highly prevalent and is associated with poor clinical outcomes in end-stage renal disease (ESRD) patients. Inadequate diet and a state of persistent catabolism play major roles in predisposing these patients to uremic malnutrition and appear to have an additive effect on overall outcome. Recent studies highlight the existence of a complex syndrome involving chronic inflammation, metabolic abnormalities, and hormonal derangements contributing to the increased morbidity and mortality observed in ESRD patients. Novel strategies such as appetite stimulants, anti-inflammatory drugs, and anabolic hormones along with conventional nutritional supplementation may provide potential interventions to improve clinical outcome in ESRD patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acidosis / metabolism
  • Animals
  • Cytokines / metabolism
  • Humans
  • Inflammation / physiopathology
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / complications
  • Nutrition Assessment
  • Nutrition Disorders / etiology*
  • Nutrition Disorders / physiopathology
  • Nutrition Disorders / therapy
  • Nutritional Status
  • Parenteral Nutrition
  • Uremia / complications*
  • Uremia / physiopathology


  • Cytokines