Contrasting urban and rural lifestyles of memory CD8+ T cells

Immunity. 2003 May;18(5):584-6. doi: 10.1016/s1074-7613(03)00118-3.


Memory CD8(+) T cells in lymphoid tissue exhibit an unexpectedly high apoptosis rate, while memory cells located in several nonlymphoid tissues do not. This may be because the lymphoid CD8(+) memory T cell repertoire is being continuously updated, while the tissue repertoire is more stable.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Survival / immunology
  • Immunologic Memory*
  • Lymphoid Tissue / immunology
  • Male
  • Mice
  • Organ Specificity / immunology