Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

Immunity. 2003 May;18(5):675-85. doi: 10.1016/s1074-7613(03)00111-0.


The Notch genes play a key role in cellular differentiation. The significance of Notch1 during thymocyte development is well characterized, but the function of Notch2 is poorly understood. Here we demonstrate that Notch2 but no other Notch family member is preferentially expressed in mature B cells and that conditionally targeted deletion of Notch2 results in the defect of marginal zone B (MZB) cells and their presumed precursors, CD1d(hi) fraction of type 2 transitional B cells. Among Notch target genes, the expression level of Deltex1 is prominent in MZB cells and strictly dependent on that of Notch2, suggesting that Deltex1 may play a role in MZB cell differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism*
  • Carrier Proteins*
  • Cell Differentiation / genetics*
  • Cell Differentiation / immunology
  • Cell Lineage / genetics*
  • Cell Lineage / immunology
  • Heterozygote
  • Mice
  • Mice, Knockout
  • Proteins / metabolism
  • Receptor, Notch2
  • Receptors, Cell Surface / biosynthesis
  • Receptors, Cell Surface / genetics*


  • Carrier Proteins
  • Notch2 protein, mouse
  • Proteins
  • Receptor, Notch2
  • Receptors, Cell Surface
  • deltex protein, vertebrate