Don't shoot the (second) messenger: endomembrane transporters and binding proteins modulate cytosolic Ca2+ levels

Curr Opin Plant Biol. 2003 Jun;6(3):257-62. doi: 10.1016/s1369-5266(03)00036-0.


Ca(2+) signal transduction requires the meticulous regulation of cytosolic Ca(2+) levels. Endomembrane Ca(2+) transporters and binding proteins are important components in partitioning these Ca(2+) signals to mediate cellular activity. Recently, many of these proteins have been characterized and mutant analysis suggests that these transporters form a network. Future attempts to manipulate plant Ca(2+) signaling must address all aspects of this complex.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Transport / genetics
  • Biological Transport / physiology
  • Calcium / physiology*
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / physiology*
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / physiology*
  • Organelles / physiology
  • Plants / genetics
  • Plants / metabolism*
  • Second Messenger Systems / genetics
  • Second Messenger Systems / physiology*


  • Calcium-Binding Proteins
  • Membrane Transport Proteins
  • Calcium