Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease

Arch Neurol. 2003 May;60(5):767-70. doi: 10.1001/archneur.60.5.767.


Background: The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons.

Objective: To describe a patient with sporadic Creutzfeldt-Jakob disease (sCJD) who had a clinical history and initial electroencephalogram and magnetic resonance imaging findings consistent with variant CJD (vCJD).

Results: Results of a repeated electroencephalogram were suggestive of sCJD, and a subsequent brain biopsy confirmed this diagnosis.

Conclusions: This case cautions against relying solely on T2- and diffusion-weighted pulvinar hyperintensity and clinical features to differentiate between vCJD and sCJD, and further supports established diagnostic criteria for vCJD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Brain / pathology
  • Creutzfeldt-Jakob Syndrome / classification
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Diagnosis, Differential
  • Electroencephalography
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Pulvinar / pathology