Abstract
Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.
MeSH terms
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Child
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Child, Preschool
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Chromatography, High Pressure Liquid
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Down Syndrome / enzymology
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Down Syndrome / metabolism*
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Female
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Glutathione / metabolism*
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Glutathione Reductase / metabolism*
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Glutathione Transferase / metabolism*
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Humans
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Male
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Reactive Oxygen Species / metabolism
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Superoxide Dismutase / metabolism*
Substances
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Reactive Oxygen Species
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Superoxide Dismutase
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Glutathione Reductase
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Glutathione Transferase
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Glutathione