Glutathione metabolism and antioxidant enzymes in children with Down syndrome

J Pediatr. 2003 May;142(5):583-5. doi: 10.1067/mpd.2003.203.


Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

MeSH terms

  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Down Syndrome / enzymology
  • Down Syndrome / metabolism*
  • Female
  • Glutathione / metabolism*
  • Glutathione Reductase / metabolism*
  • Glutathione Transferase / metabolism*
  • Humans
  • Male
  • Reactive Oxygen Species / metabolism
  • Superoxide Dismutase / metabolism*


  • Reactive Oxygen Species
  • Superoxide Dismutase
  • Glutathione Reductase
  • Glutathione Transferase
  • Glutathione