Genetic diversity of a canine coronavirus detected in pups with diarrhoea in Italy

J Virol Methods. 2003 Jun 9;110(1):9-17. doi: 10.1016/s0166-0934(03)00081-8.


The sequence of the S gene of a field canine coronavirus (CCoV), strain Elmo/02, revealed low nucleotide (61%) and amino acid (54%) identity to reference CCoV strains. The highest correlation (77% nt and 81.7% aa) was found with feline coronavirus type I. A PCR assay for the S gene of strain Elmo/02 detected analogous CCoVs of different geographic origin, all which exhibited at least 92-96% nucleotide identity to each other and to strain Elmo/02. The evident genetic divergence between the reference CCoV strains and the newly identified Elmo/02-like CCoVs strongly suggests that a novel genotype of CCoV is widespread in the dog population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cats
  • Coronavirus Infections / veterinary*
  • Coronavirus Infections / virology
  • Coronavirus, Canine / classification
  • Coronavirus, Canine / genetics*
  • Coronavirus, Feline / genetics
  • Diarrhea / veterinary*
  • Diarrhea / virology
  • Dog Diseases / virology*
  • Dogs
  • Feces
  • Genetic Variation*
  • Genotype
  • Italy
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / genetics*
  • Molecular Sequence Data
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / genetics*


  • Membrane Glycoproteins
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins

Associated data

  • GENBANK/AY170345