The role of natural killer T cells and other T cell subsets against infection by the pre-erythrocytic stages of malaria parasites

Microbes Infect. 2003 May;5(6):499-506. doi: 10.1016/s1286-4579(03)00072-8.

Abstract

T cells are critical mediators of immunity to the pre-erythrocytic stages of malaria parasites. In this review, we survey the role of the various T cell subsets in combating the pre-erythrocytic stages; in particular, the role of NK T cells. Moreover, we show how studies using malaria models have revealed a unique behavior of NK T cells, namely the bridging of innate and adaptive immunity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Erythrocytes / parasitology
  • Humans
  • Killer Cells, Natural / immunology*
  • Liver / parasitology
  • Malaria / immunology*
  • Malaria / parasitology*
  • Malaria Vaccines / immunology
  • Plasmodium / growth & development*
  • Plasmodium / immunology*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Malaria Vaccines