Offspring sex ratio is not associated with parental GSTT1 and GSTM1 null genotypes

Reprod Toxicol. 2003 May-Jun;17(3):345-7. doi: 10.1016/s0890-6238(03)00006-6.


The present study evaluated the association between offspring sex ratio and parental inherited variations of xenobiotic metabolism by glutathione S-transferase (GST) T1 and GSTM1. Polymorphisms of GSTT1 and GSTM1 were investigated in 235 Iranian Muslims (153 males, 82 females) using polymerase chain reaction-based method. Statistical analysis of 890 offspring in the study families revealed that there was no association between GSTM1 null genotype of either the fathers (OR=1.28; 95% CI=0.88-1.85; P=0.17) or mothers (OR=0.77; 95% CI=0.49-1.19; P=0.22) and offspring sex ratio. There was no association between paternal GSTT1 null genotype and sex ratio in offspring (OR=1.04; 95% CI=0.71-1.54; P=0.84), whereas there was a weak association between maternal GSTT1 null genotype and offspring sex ratio (OR=1.54; 95% CI=1.0-2.38; P=0.05). Combination of parental GSTT1 and GSTM1 genotypes showed no association with offspring sex ratio.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Genetics, Population
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Iran
  • Male
  • Parents*
  • Polymorphism, Genetic*
  • Quantitative Trait, Heritable*
  • Sex Ratio


  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1