Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria

Infect Immun. 2003 Jun;71(6):3648-51. doi: 10.1128/IAI.71.6.3648-3651.2003.

Abstract

Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / physiology
  • Malaria, Cerebral / etiology*
  • Malaria, Cerebral / pathology
  • Mesencephalon / pathology
  • Mice
  • Mice, Inbred C57BL
  • Receptors, CCR2
  • Receptors, CCR5 / physiology
  • Receptors, Chemokine / physiology*

Substances

  • Ccr2 protein, mouse
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine