Abstract
A novel compound, 6-benzylamino-3-hydroxyhexacyclo [6.5.0.0(3, 7).0(4, 12).0(5, 10).0(9, 13)]-tridecane, was synthesized as part of an ongoing study to explore the ion channel activity of polycyclic cage amines. The known polycyclic calcium channel antagonist, 8-benzylamino-8, 11-oxapentacyclo [5.4.0.0(2, 6).0(3, 10).0(5, 9)]undecane (NGP 1-01) served as the lead compound and as a positive control for channel activity. The title compound inhibited calcium currents at test concentrations of 10 microM at depolarized membrane potentials (in the potential range where the L-type calcium channel inactivates). At the test concentrations modulating effects were also observed for sodium and the delayed rectifier potassium currents. Due to its activity at both Ca(2+) and Na(+) channels, this compound may offer utility as a cardiovascular and/or neuroprotecting agent.
MeSH terms
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Animals
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / pharmacology*
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Calcium Channel Blockers / chemistry
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Calcium Channel Blockers / pharmacology*
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Calcium Channels, L-Type / drug effects
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Calcium Channels, L-Type / physiology
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Calcium Channels, T-Type / drug effects
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Calcium Channels, T-Type / physiology
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Delayed Rectifier Potassium Channels
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Guinea Pigs
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Heart / drug effects
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Heart / physiology
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Humans
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Mass Spectrometry
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Membrane Potentials / drug effects
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Patch-Clamp Techniques
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Potassium Channel Blockers / chemistry
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Potassium Channel Blockers / pharmacology*
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Potassium Channels / drug effects
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Potassium Channels / physiology
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Potassium Channels, Inwardly Rectifying / drug effects
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Potassium Channels, Inwardly Rectifying / physiology
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Potassium Channels, Voltage-Gated*
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Sodium Channel Blockers / chemistry
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Sodium Channel Blockers / pharmacology*
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Sodium Channels / drug effects
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Sodium Channels / physiology
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Structure-Activity Relationship
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Time Factors
Substances
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6-benzylamino-3-hydroxyhexa-cyclo(6.5.0.0(3,7).0(4,12).0(5,10).0(9,13) )tridecane
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Bridged-Ring Compounds
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Calcium Channel Blockers
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Calcium Channels, L-Type
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Calcium Channels, T-Type
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Delayed Rectifier Potassium Channels
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Potassium Channel Blockers
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Potassium Channels, Voltage-Gated
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Sodium Channel Blockers
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Sodium Channels