Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A

J Nat Prod. 2003 May;66(5):703-5. doi: 10.1021/np0205699.


Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Diterpenes, Clerodane
  • Feeding Behavior / drug effects
  • Mexico
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Salvia / chemistry*
  • Spodoptera / drug effects
  • Tenebrio / drug effects


  • Diterpenes
  • Diterpenes, Clerodane
  • salvinorin D
  • salvinorin E
  • salvinorin F