Abstract
Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Candida albicans / drug effects
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Geotrichum / chemistry*
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / drug effects
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Stereoisomerism
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Thailand
Substances
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7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one
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7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one
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7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one
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Antifungal Agents
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Antimalarials
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Antitubercular Agents
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Coumarins