Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing mouse brain

Brain Res Dev Brain Res. 2003 Jun 12;143(1):105-9. doi: 10.1016/s0165-3806(03)00101-9.


TROY is a recently identified member of the tumor necrosis factor (TNF) receptor superfamily. We investigated the expression pattern of TROY mRNA in the developing central nervous system by the in situ hybridization technique. TROY mRNA was strongly expressed in the ventricular zone and the subventricular zone, which contain neuronal and glial precursors during mouse embryogenesis. Its spatial and temporal expression patterns suggest that TROY plays some important roles in neurogenesis of embryonic stages.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain / anatomy & histology
  • Brain / embryology
  • Brain / metabolism*
  • Embryo, Mammalian
  • Female
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization / methods
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA, Messenger / biosynthesis
  • Receptors, Tumor Necrosis Factor / biosynthesis*
  • Receptors, Tumor Necrosis Factor / chemistry
  • Receptors, Tumor Necrosis Factor / genetics


  • RNA, Messenger
  • Receptors, Tumor Necrosis Factor
  • TNFRSF19 protein, human