Innate immunity and pathogen-host interaction

Vaccine. 2003 Jun 1;21 Suppl 2:S12-23. doi: 10.1016/s0264-410x(03)00195-6.


The skin and contiguous mucosal surfaces define the primary locus of interaction between host and micro-organisms. In this review, we focus on the innate immune system in the mucosa, which manages to deal with invading pathogens, the mechanisms that organisms have evolved in order to circumvent this primary defensive barrier and, finally, potential therapeutic manipulation of the innate immune system that was the focus of meeting at a Euroconference/Workshop on "Novel Strategies of Mucosal Immunisation through Exploitation of Mechanisms of Innate Immunity in Pathogen-Host Interaction", which was held in Siena, Italy, November 2002.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines / physiology
  • Collectins / physiology
  • Complement System Proteins / physiology
  • Cytokines / physiology
  • Dendritic Cells / physiology
  • Humans
  • Immunity, Innate*
  • Immunity, Mucosal*
  • Killer Cells, Natural / immunology
  • Mast Cells / physiology
  • Membrane Glycoproteins / physiology
  • Neutrophils / immunology
  • Receptors, Cell Surface / physiology
  • Signal Transduction / physiology
  • Toll-Like Receptors


  • Chemokines
  • Collectins
  • Cytokines
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors
  • Complement System Proteins