Abstract
Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna. The structure was established as olean-1alpha,3beta,22beta-triol-12-en-28-oic acid-3beta-D-glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cardiac Glycosides / chemistry
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Cardiac Glycosides / isolation & purification
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Cardiac Glycosides / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Macrophages / drug effects*
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Macrophages / metabolism
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Mice
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type II
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrometry, Mass, Fast Atom Bombardment
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Spectroscopy, Fourier Transform Infrared
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Terminalia / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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omega-N-Methylarginine / pharmacology
Substances
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Cardiac Glycosides
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Glycosides
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Triterpenes
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terminoside A
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omega-N-Methylarginine
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Nitric Oxide
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse