Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study

Cancer Lett. 2003 Jun 10;195(2):177-83. doi: 10.1016/s0304-3835(03)00182-4.


Association between genetic polymorphisms of CYP1A1 and familial prostate cancer risk was examined by a case-control study of 185 individuals. Although the individual analysis of m1 or m2 genotype of CYP1A1 showed no significant association with prostate cancer risk, the presence of any mutated alleles significantly increased prostate cancer risk in comparison with wild-type genotypes by combination analysis (odds ratio [OR]=2.38; 95% confidence interval [CI]=1.72-3.29; P=0.0069). Furthermore, metastatic cancer had a significant association with mutated alleles of m1 and m2. These finding suggested that CYP1A1 polymorphisms has an association with prostate cancer risk, especially with progression of prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / enzymology
  • Adenocarcinoma / epidemiology*
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Case-Control Studies
  • Cytochrome P-450 CYP1A1 / genetics*
  • Disease Progression
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Prostatic Neoplasms / enzymology
  • Prostatic Neoplasms / epidemiology*
  • Risk


  • Neoplasm Proteins
  • Cytochrome P-450 CYP1A1