Prenatal diagnosis of congenital leukemia in a fetus at 25 weeks' gestation with Down syndrome: case report and review of the literature

Ultrasound Obstet Gynecol. 2003 May;21(5):486-9. doi: 10.1002/uog.87.

Abstract

Leukemia in a hydropic fetus with hepatosplenomegaly and Down syndrome was diagnosed at 25 weeks' gestation. Spontaneous demise occurred 10 days after the cordocentesis. A review of the literature of the seven cases described antenatally and 10 cases described in the immediate neonatal period or on examination of the stillborn baby is presented.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cordocentesis
  • Diagnosis, Differential
  • Down Syndrome / complications*
  • Female
  • Fetal Death
  • Gestational Age
  • Hepatomegaly / complications
  • Humans
  • Hydrops Fetalis / complications
  • Leukemia / congenital
  • Leukemia / diagnostic imaging*
  • Pregnancy
  • Pregnancy Trimester, Third
  • Ultrasonography, Prenatal / methods*