The Insulin-Sensitizing Role of the Fat Derived Hormone Adiponectin

Curr Pharm Des. 2003;9(17):1411-8. doi: 10.2174/1381612033454766.

Abstract

Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adiponectin
  • Adipose Tissue / metabolism
  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Glucose / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins*
  • Mice
  • Mice, Knockout
  • Protein Biosynthesis*
  • Protein Processing, Post-Translational
  • Proteins / metabolism*
  • Proteins / pharmacology
  • Recombinant Proteins / pharmacology

Substances

  • Adiponectin
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Recombinant Proteins
  • Glucose