Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 168 (11), 1439-42

Serotonin Syndrome: A Brief Review

Affiliations
Review

Serotonin Syndrome: A Brief Review

Philippe Birmes et al. CMAJ.

Figures

None
Fig. 1: Mechanisms of serotonin syndrome. (1) Increased doses of L-tryptophan will proportionally increase 5-hydroxytryptamine (5-HT or serotonin) formation. (2) Amphetamines and other drugs increase the release of stored serotonin. (3) Inhibition of serotonin metabolism by monoamine oxidase (MAO) inhibitors will increase presynaptic 5-HT concentration. (4) Impairment of 5-HT transport into the presynaptic neuron by uptake blockers (e.g., selective serotonin reuptake inhibitors, tricyclic antidepressants) increases synaptic 5-HT concentration. (5) Direct serotonin agonists can stimulate postsynaptic 5-HT receptors. (6) Lithium increases postsynaptic receptor responses. Adapted with permission from Elsevier Science (Critical Care Clinics 1997;13[4]:763-83). Photo: Chesley Sheppard
Box 1
Box 1
Box 2
Box 2

Comment in

Similar articles

See all similar articles

Cited by 34 articles

See all "Cited by" articles

MeSH terms

Feedback