Cancer and the FRA3B/FHIT fragile locus: it's a HIT

Br J Cancer. 2003 May 19;88(10):1501-6. doi: 10.1038/sj.bjc.6600937.


The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival.

MeSH terms

  • Acid Anhydride Hydrolases
  • Apoptosis
  • Base Pair Mismatch
  • Cell Division
  • Disease Progression
  • Genes, Tumor Suppressor
  • Humans
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / pharmacology
  • Neoplasms / genetics*
  • Neoplasms / physiopathology
  • Survival


  • Neoplasm Proteins
  • fragile histidine triad protein
  • Acid Anhydride Hydrolases