Abstract
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Bacteria / drug effects
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Bacteria / enzymology
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Hydro-Lyases / antagonists & inhibitors
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Hydro-Lyases / chemistry
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Hydro-Lyases / metabolism*
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Plants / enzymology
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Shikimic Acid / metabolism*
Substances
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Enzyme Inhibitors
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Shikimic Acid
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Hydro-Lyases
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3-dehydroquinate dehydratase