Genetic linkage and imprinting effects on body mass index in children and young adults

Eur J Hum Genet. 2003 Jun;11(6):425-32. doi: 10.1038/sj.ejhg.5200979.


Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p11.2-pter near the marker D20S851 (LOD(Total)=4.08, P=0.000046) and near the marker D20S482 (LOD(Total) =3.55, P=0.00016), and Chromosome 16 at 16p13 near the marker ATA41E04 (LOD(Total) =3.12, P=0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Body Mass Index*
  • Child
  • Child, Preschool
  • Chromosomes, Human, Pair 16 / genetics
  • Chromosomes, Human, Pair 16 / physiology
  • Chromosomes, Human, Pair 20 / genetics
  • Chromosomes, Human, Pair 20 / physiology
  • Genetic Linkage / genetics*
  • Genetic Linkage / physiology*
  • Genomic Imprinting / genetics*
  • Humans
  • Models, Genetic*