Diffuse large B-cell lymphoma: insights gained from gene expression profiling

Int J Hematol. 2003 May;77(4):321-9. doi: 10.1007/BF02982638.


Analysis of global gene expression with DNA microarrays has great potential to improve the understanding of tumorigenesis advance tumor diagnosis and classification, and affect cancer treatment. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. However, we now realize that the disease is extremely heterogeneous. This review summarizes the progress in understanding DLBCL that has been made as a result of the application of gene expression profiling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Gene Expression Profiling / methods*
  • Humans
  • Lymphoma, B-Cell / genetics
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Signal Transduction / genetics