Polar expeditions--provisioning the centrosome for mitosis

Nat Cell Biol. 2003 Jun;5(6):505-11. doi: 10.1038/ncb0603-505.

Abstract

It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.

Publication types

  • Review

MeSH terms

  • Animals
  • Aurora Kinases
  • Centrioles / chemistry
  • Centrioles / physiology
  • Centrioles / ultrastructure
  • Centrosome / enzymology
  • Centrosome / physiology*
  • Drosophila Proteins*
  • Dyneins / metabolism
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Mitosis*
  • Models, Biological
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Tubulin / physiology

Substances

  • Drosophila Proteins
  • Microtubule-Associated Proteins
  • Tubulin
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • Dyneins