IQGAP proteins are integral components of cytoskeletal regulation

EMBO Rep. 2003 Jun;4(6):571-4. doi: 10.1038/sj.embor.embor867.

Abstract

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cytoskeletal Proteins / metabolism
  • Cytoskeleton / metabolism*
  • Humans
  • Microfilament Proteins / chemistry*
  • Microfilament Proteins / physiology*
  • Models, Biological
  • Neoplasms / metabolism
  • Protein Binding
  • Protein Structure, Tertiary
  • Signal Transduction
  • Trans-Activators / metabolism
  • Transcription, Genetic
  • beta Catenin
  • ras GTPase-Activating Proteins*

Substances

  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • IQ motif containing GTPase activating protein 1
  • Microfilament Proteins
  • Trans-Activators
  • beta Catenin
  • ras GTPase-Activating Proteins