The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic lever disease

Clin Pharmacol Ther. 1976 Jul;20(1):81-9. doi: 10.1002/cpt197620181.


The pharmacokinetics after oral administration of 1,200 mg antipyrine and intravenous administration of 0.5 mg/kg indocyanine green have been investigated in 6 normal subjects and in 20 patients with chronic liver disease of varying etiology. Severe impairment of liver function associated with a decrease in serum albumin, elevation in serum bilirubin, or prolongation in prothrombin time correlated with a fall in the clearance of both drugs. The clearance of the two drugs correlated well in normal subjects and in patients with chronic liver disease. The presence of a surgical portacaval anastomosis was associated with a lower indocyanine green clearance for comparable clearance of antipyrine. The concept of functioning hepatic parenchymal mass is proposed as a common rate-limiting parameter for the elimination of the two drugs.

MeSH terms

  • Adult
  • Aged
  • Antipyrine / metabolism*
  • Bilirubin / blood
  • Chronic Disease
  • Female
  • Half-Life
  • Humans
  • Indocyanine Green / metabolism*
  • Kinetics
  • Liver Diseases / metabolism*
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Prothrombin Time
  • Serum Albumin / metabolism


  • Serum Albumin
  • Indocyanine Green
  • Bilirubin
  • Antipyrine