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. 2003 Oct;42(10):1164-7.
doi: 10.1093/rheumatology/keg316. Epub 2003 May 30.

Paucity of Sjogren-like Syndrome in a Cohort of HIV-1-positive Patients in the HAART Era. Part II

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Paucity of Sjogren-like Syndrome in a Cohort of HIV-1-positive Patients in the HAART Era. Part II

G D Panayiotakopoulos et al. Rheumatology (Oxford). .

Abstract

Objective: This study was performed in order to investigate the prevalence of Sjögren-like syndrome (SLS) in the highly active anti-retroviral therapy (HAART) era in a cohort of HIV-1-positive Greek patients.

Methods: One hundred and thirty-one unselected patients were screened by the validated European Union (EU) criteria for Sjögren's syndrome. Of the 31 who gave a positive EU-validated questionnaire, 17 consented to undergo minor salivary gland biopsy and other tests.

Results: Only two patients had a positive salivary gland biopsy and both belonged to the non-compliant HAART group, whereas none of the compliant HAART patients had histological findings.

Conclusions: It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.

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