Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II

Rheumatology (Oxford). 2003 Oct;42(10):1164-7. doi: 10.1093/rheumatology/keg316. Epub 2003 May 30.


Objective: This study was performed in order to investigate the prevalence of Sjögren-like syndrome (SLS) in the highly active anti-retroviral therapy (HAART) era in a cohort of HIV-1-positive Greek patients.

Methods: One hundred and thirty-one unselected patients were screened by the validated European Union (EU) criteria for Sjögren's syndrome. Of the 31 who gave a positive EU-validated questionnaire, 17 consented to undergo minor salivary gland biopsy and other tests.

Results: Only two patients had a positive salivary gland biopsy and both belonged to the non-compliant HAART group, whereas none of the compliant HAART patients had histological findings.

Conclusions: It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active*
  • Biopsy
  • Female
  • Follow-Up Studies
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV-1*
  • Humans
  • Male
  • Middle Aged
  • Salivary Glands, Minor / pathology
  • Sjogren's Syndrome / pathology
  • Sjogren's Syndrome / virology*


  • Anti-HIV Agents