Low-resolution molecular replacement using a six-dimensional search

Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1016-9. doi: 10.1107/s090744490300739x. Epub 2003 May 23.


A parallel-aware program MPI_FSEARCH has been implemented to perform molecular replacement using an exhaustive six-dimensional search. In particular, the program can be used to deal with diffraction data at very low resolution (d > 10 A) that would normally not be appropriate for other molecular-replacement programs such as AMoRe and CNS. Although an envelope constructed from a PDB (Protein Data Bank) file was tested in the present study, the program can be used to perform low-resolution molecular replacement with an envelope derived from various sources such as electron microscopy or small-angle solution X-ray scattering.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 6-Phytase / chemistry
  • Aspergillus fumigatus / enzymology
  • Computer Simulation
  • Crystallography, X-Ray / methods*
  • Models, Molecular
  • Molecular Conformation
  • Proteins / chemistry*
  • Software


  • Proteins
  • 6-Phytase