Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

Br J Cancer. 2003 May 6;88(9):1400-2. doi: 10.1038/sj.bjc.6600923.


We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCalpha expression in clinical specimens was determined by comparing PKCalpha expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCalpha expression may predict TAM treatment failure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Biopsy
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Predictive Value of Tests
  • Protein Kinase C / metabolism*
  • Protein Kinase C-alpha
  • Recurrence
  • Retrospective Studies
  • Tamoxifen / therapeutic use*
  • Treatment Failure


  • Antineoplastic Agents, Hormonal
  • Tamoxifen
  • PRKCA protein, human
  • Protein Kinase C
  • Protein Kinase C-alpha