Rocks: multifunctional kinases in cell behaviour

Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56. doi: 10.1038/nrm1128.

Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Gene Expression Regulation*
  • Humans
  • Insulin / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Models, Biological
  • Muscle, Smooth / metabolism
  • Phagocytosis
  • Phosphorylation
  • Phylogeny
  • Protein Isoforms
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction
  • rho-Associated Kinases

Substances

  • Insulin
  • Intracellular Signaling Peptides and Proteins
  • Protein Isoforms
  • Protein-Serine-Threonine Kinases
  • rho-Associated Kinases