A Fuzzy Mitochondrial Fusion Apparatus Comes Into Focus

Nat Rev Mol Cell Biol. 2003 Jun;4(6):468-78. doi: 10.1038/nrm1125.


Membrane fusion is fundamental to eukaryotic life. Unlike the predominant intracellular fusion machineries that fuse compartments bounded by a single membrane, the mitochondrial fusion machinery must sequentially fuse the outer and inner mitochondrial membranes. These coordinated fusion events rely on a transmembrane GTPase that is known as fuzzy onions or Fzo. Recent studies have revealed that Fzo has an evolutionarily conserved role in mitochondrial fusion, and they take the first strides in determining the molecular nature of such a role.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Cell Membrane / physiology
  • Drosophila Proteins*
  • GTP Phosphohydrolases / chemistry*
  • GTP Phosphohydrolases / physiology*
  • Gene Deletion
  • Humans
  • Membrane Fusion*
  • Membrane Proteins / physiology*
  • Microscopy, Fluorescence
  • Mitochondria / physiology*
  • Models, Biological
  • Phenotype
  • Protein Structure, Tertiary
  • Saccharomycetales / physiology*


  • Drosophila Proteins
  • Membrane Proteins
  • Fzo protein, Drosophila
  • GTP Phosphohydrolases