Possible role of matriptase in the diagnosis of ovarian cancer

Expert Rev Mol Diagn. 2003 May;3(3):331-8. doi: 10.1586/14737159.3.3.331.


There are increasing data that suggest a role for the serine protease matriptase and its inhibitor, hepatocyte growth factor activator inhibitor-1, in the pathogenesis and progression of ovarian cancer. This review will discuss the matriptase/inhibitor system in the context of ovarian cancer and examine the possibility that this system might be a useful therapeutic and/or diagnostic target in this disease.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Disease Progression
  • Enzyme Activation
  • Female
  • Humans
  • Ovarian Neoplasms / classification
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / therapy
  • Serine Endopeptidases / analysis
  • Serine Endopeptidases / physiology*
  • Serine Proteinase Inhibitors / analysis
  • Serine Proteinase Inhibitors / physiology
  • Trypsin / analysis
  • Trypsin / physiology*


  • Biomarkers, Tumor
  • Serine Proteinase Inhibitors
  • Serine Endopeptidases
  • matriptase
  • ST14 protein, human
  • Trypsin