Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

Partha P Manna; Andrés Jaramillo; Kanchana Majumder; Lacey G Campbell; Timothy P Fleming; Jill R Dietz; John F Dipersio; T Mohanakumar

doi:10.1023/a:1023323509888

Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

Breast Cancer Res Treat. 2003 May;79(1):133-6. doi: 10.1023/a:1023323509888.

Authors

Partha P Manna¹, Andrés Jaramillo, Kanchana Majumder, Lacey G Campbell, Timothy P Fleming, Jill R Dietz, John F Dipersio, T Mohanakumar

Affiliation

¹ Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

PMID: 12779090
DOI: 10.1023/a:1023323509888

Abstract

Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antibody Specificity*
Breast Neoplasms / immunology*
Breast Neoplasms / therapy
CD8-Positive T-Lymphocytes / immunology*
Cell Line, Transformed
Cytotoxicity, Immunologic / immunology*
Dendritic Cells / immunology*
Humans
Immunotherapy, Adoptive*
Lymphocytes, Tumor-Infiltrating / immunology
Mammaglobin A
Neoplasm Proteins / immunology*
Tumor Cells, Cultured
Uteroglobin / immunology*

Substances

Mammaglobin A
Neoplasm Proteins
SCGB2A2 protein, human
Uteroglobin