Abstract
In the eukaryotic cell cycle, the G2-M transition is regulated by a counteracting kinase/phosphatase mechanism. A novel player, Tome-1, has now been found to trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'.
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Animals
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Cell Cycle Proteins / metabolism*
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Cell Cycle Proteins / physiology
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G2 Phase / physiology*
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Mitosis / physiology*
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SKP Cullin F-Box Protein Ligases / metabolism
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Signal Transduction / physiology*
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Ubiquitin-Protein Ligase Complexes / metabolism
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Xenopus
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Xenopus Proteins / metabolism*
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Xenopus Proteins / physiology
Substances
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CDCA3 protein, Xenopus
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Cell Cycle Proteins
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Xenopus Proteins
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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SKP Cullin F-Box Protein Ligases