Mitotic Entry: Tipping the Balance

Curr Biol. 2003 May 27;13(11):R445-6. doi: 10.1016/s0960-9822(03)00367-1.

Abstract

In the eukaryotic cell cycle, the G2-M transition is regulated by a counteracting kinase/phosphatase mechanism. A novel player, Tome-1, has now been found to trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'.

Publication types

  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle Proteins / metabolism*
  • Cell Cycle Proteins / physiology
  • G2 Phase / physiology*
  • Mitosis / physiology*
  • SKP Cullin F-Box Protein Ligases / metabolism
  • Signal Transduction / physiology*
  • Ubiquitin-Protein Ligase Complexes / metabolism
  • Xenopus
  • Xenopus Proteins / metabolism*
  • Xenopus Proteins / physiology

Substances

  • CDCA3 protein, Xenopus
  • Cell Cycle Proteins
  • Xenopus Proteins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • SKP Cullin F-Box Protein Ligases