Chk1 and Chk2 Kinases in Checkpoint Control and Cancer

Cancer Cell. 2003 May;3(5):421-9. doi: 10.1016/s1535-6108(03)00110-7.

Abstract

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / metabolism
  • Cell Cycle
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • Colonic Neoplasms / enzymology
  • DNA Repair
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Mutation*
  • Neoplasms / enzymology*
  • Neoplasms / genetics*
  • Protein Kinases / genetics
  • Protein Kinases / physiology*
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Tumor Suppressor Protein p53
  • Protein Kinases
  • Checkpoint Kinase 2
  • CHEK1 protein, human
  • CHEK2 protein, human
  • Checkpoint Kinase 1
  • Chek1 protein, mouse
  • Chek2 protein, mouse
  • Protein-Serine-Threonine Kinases