The role of cytokines in prostatitis

World J Urol. 2003 Jun;21(2):95-9. doi: 10.1007/s00345-003-0335-2. Epub 2003 May 29.


There is substantiating evidence to support the role of the immune system in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inflammation of the prostate is mediated through the cytokine-induced expression of several factors such as chemokines, inducible nitric oxide synthase, and cyclooxygenase-2. The balance between the effects of proinflammatory and anti-inflammatory cytokines determines the outcome of the inflammatory process. Several proinflammatory and anti-inflammatory cytokines have been identified in CPPS patients, their roles characterized, and their inter-relationships defined. Study of this system will provide further insights into the etiology of CP/CPPS, and lead the way for the development of novel therapeutic approaches for this morbid condition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease
  • Cytokines / biosynthesis
  • Cytokines / genetics
  • Cytokines / immunology*
  • Humans
  • Male
  • Pelvic Pain / complications
  • Pelvic Pain / genetics
  • Pelvic Pain / immunology*
  • Pelvic Pain / physiopathology
  • Prostatitis / complications
  • Prostatitis / genetics
  • Prostatitis / immunology*
  • Prostatitis / physiopathology


  • Cytokines