Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

Ann Neurol. 2003 Jun;53(6):819-22. doi: 10.1002/ana.10606.


In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / metabolism*
  • Multiple Sclerosis, Relapsing-Remitting / metabolism*
  • Osteopontin
  • Sialoglycoproteins / blood
  • Sialoglycoproteins / metabolism*


  • SPP1 protein, human
  • Sialoglycoproteins
  • Osteopontin